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List of nominees. Winners are highlighted.
The show was held at the Staples Center (Los Angeles), on September 13, 2000.
| Category | Artist | Video | Director |
|---|---|---|---|
| Best music video | Gloria Estefan | No me dejes de querer [winner] | Emilio Estefan | los Fabulosos Cadillacs | La vida | Jose Luis Garcia | la Ley | Aquí | Gustavo Garzon & Beto Cuevas | Jennifer Lopez & Marc Anthony | No me ames | Kevin Bray | Shakira | Eyes like yours (ojos así) | Mark Kohr |